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Paeonia lactiflora
Panax ginseng
Plantago afra
Platycodon grandiflorum
Piper methysticum
Polygala senega
Prunus africana
Prunus armeniaca
Plantago ovata
Pimpinella anisum
Passiflora incarnata
Psidium guajava
Punica granatum


 

 

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Untitled Document Paeonia lactiflora Pallas (Paeonaceae)

Synonyms
Paeonia albiflora Pallas., P. edulis Salisb., P. officinalis Thunb.

Description
Paeonia lactiflora Pallas is a perennial herb, 50–80 cm high, with a stout branched root. Leaves alternate and biternately compound, the ultimate segments redveined, oblong-elliptical. The leaflets are narrow-ovate or elliptical, 8–12cm long and 2–4 cm wide. The petioles are 6–10 cm long. Flowers large (5–10 cm in diameter), solitary, and red, white, or purple. Sepals 4, herbaceous, persistent. Petals 5–10, larger than sepals. Stamens numerous and anthers yellow; carpels 3–5, many-seeded. Fruit, 3–5 coriaceous few-seeded follicles. Seeds large, subglobose; testa thick

Plant material of interest
dried root (Radix Paeoniae)

Chemical assays
Contains not less than 2.0% of paeoniflorin, assayed by a combination of thin-layer chromatographic–spectrophotometric methods or by highperformance liquid chromatography

Major chemical constituents
Paeoniflorin, a monoterpene glycoside that is the major active constituent, is present in the range of 0.05–6.01%

Dosage forms
Crude plant material, powder, and decoction. Store in a ventilated dry environment protected from light

Medicinal uses
Uses supported by clinical data
None.

Uses described in pharmacopoeias and well established documents
As an analgesic, anti-inflammatory and antispasmodic drug in the treatment of amenorrhoea, dysmenorrhoea, and pain in the chest and abdomen. Radix Paeoniae is also used to treat dementia, headache, vertigo, spasm of the calf muscles, liver disease, and allergies, and as an anticoagulant.

Uses described in traditional medicine
The treatment of atopic eczema, boils, and sores; to reduce fevers, induce sterility, and treat burns

Proven pharmacological activity
Animal studies
Antispasmodic, Antiinflammatory, Analgesic, Platelet aggregation inhibitor, Hepatoprotector, Antidementia

Contraindications
Reports of traditional use indicate that Radix Paeoniae may have abortifacient activity; therefore, the use of Radix Paeoniae in pregnancy is contraindicated.

Warnings
No information available.

Precautions
Drug interactions
Radix Paeoniae should not be combined with Fritillaria verticillata, Cuscuta japonica, and Rheum officinale.

Carcinogenesis, mutagenesis, impairment of fertility
Hot-water or methanol extracts of Radix Paeoniae are not mutagenic in vitro.

Pregnancy: non-teratogenic effects
See Contraindications.

Nursing mothers
Excretion of the drug into breast milk and its effects on the newborn have not been established; therefore, use of the drug during lactation is not recommended.

Paediatric use
No information available; therefore, use of Radix Paeoniae in children is not recommended.

Other precautions
No information available about general precautions, drug and laboratory test interactions, or teratogenic effects on pregnancy.

Adverse reactions
No information available.

Posology
Maximum daily oral dose of crude plant material, 6–15g, standardized for paeoniflorin.

 

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