Paeonia lactiflora Pallas (Paeonaceae)
Paeonia albiflora Pallas., P. edulis Salisb., P. officinalis Thunb.
Paeonia lactiflora Pallas is a perennial herb, 50–80 cm high, with a stout
branched root. Leaves alternate and biternately compound, the ultimate segments
redveined, oblong-elliptical. The leaflets are narrow-ovate or elliptical, 8–12cm
long and 2–4 cm wide. The petioles are 6–10 cm long. Flowers large
(5–10 cm in diameter), solitary, and red, white, or purple. Sepals 4,
herbaceous, persistent. Petals 5–10, larger than sepals. Stamens numerous
and anthers yellow; carpels 3–5, many-seeded. Fruit, 3–5 coriaceous
few-seeded follicles. Seeds large, subglobose; testa thick
Plant material of interest
dried root (Radix Paeoniae)
Contains not less than 2.0% of paeoniflorin, assayed by a combination of thin-layer
chromatographic–spectrophotometric methods or by highperformance liquid
Major chemical constituents
Paeoniflorin, a monoterpene glycoside that is the major active constituent,
is present in the range of 0.05–6.01%
Crude plant material, powder, and decoction. Store in a ventilated dry environment
protected from light
Uses supported by clinical data
Uses described in pharmacopoeias and
well established documents
As an analgesic, anti-inflammatory and antispasmodic drug in the treatment of
amenorrhoea, dysmenorrhoea, and pain in the chest and abdomen. Radix Paeoniae
is also used to treat dementia, headache, vertigo, spasm of the calf muscles,
liver disease, and allergies, and as an anticoagulant.
Uses described in traditional medicine
Proven pharmacological activity
The treatment of atopic eczema, boils, and sores; to reduce fevers, induce sterility,
and treat burns
Antispasmodic, Antiinflammatory, Analgesic, Platelet aggregation inhibitor, Hepatoprotector,
Reports of traditional use indicate that Radix Paeoniae
may have abortifacient activity; therefore, the use of Radix Paeoniae in pregnancy
No information available.
Radix Paeoniae should not be combined with Fritillaria verticillata, Cuscuta
japonica, and Rheum officinale.
Carcinogenesis, mutagenesis, impairment of fertility
Hot-water or methanol extracts of Radix Paeoniae are not mutagenic in vitro.
Pregnancy: non-teratogenic effects
Excretion of the drug into breast milk and its effects on the newborn have not
been established; therefore, use of the drug during lactation is not recommended.
No information available; therefore, use of Radix Paeoniae in children is not
No information available about general precautions, drug and laboratory test
interactions, or teratogenic effects on pregnancy.
No information available.
Maximum daily oral dose of crude plant material, 6–15g, standardized for