Centella asiatica (L.) Urban. (Apiaceae/Umbelliferae)
Centella coriacea Nannfd., Hydrocotyle asiatica L., Hydrocotyle lunata Lam.
and Trisanthus cochinchinensis Lour
Artaniyae-hindi, Asiatic pennywort, barmanimuni, barmi, bhram buti, boabok,
bodila-ba-dinku, bokkudu, brahma manduki, brahmi ghi, brahmi-buti, brahmi, bua
bok, bua-bok, centella, chhota mani-muni, chi-hsueh-ts’ao, ghibrahmi,
ghod tapre, ghodtapre, ghortapre, gotu kola, gotukola, herba pegagan, herba
kakikuda, hydrocotyle, hydrocotyle asiatique, idrocotile, imsen korokla, Indian
pennywort, Indian water navelwort, Indischer Wassernabel, karinga, karivana,
kudangal, luei gong gen, lièn tièn tháo, mandooka parni,
mandukaparni, mandukparni, manimuni, marsh pepperwort, matoyahuho, matoyahuhu,
mrang-khua, mtwigahuwu, pa-na-e-khaa-doh, phác chèn, phaknok,
phalwaen, rau má, saraswathiaaku, takip-kohol, thalkuri, thankuni, thol-kuri,
tilkushi, titjari, tono’itahi, tsubo-kusa, tungchian, vallari, vallarei,
vitovitolenge, water pennywort, waternavel, yahon-yahon, yerba de chavos
A slender trailing herb, rooting at the nodes. Leaves 1.3–6.3 cm diameter,
orbicular reniform, more or less cupped, entire, crenate or lobulate, glabrous;
leaf stalks 2–5 cm long; peduncle about 6 mm, often 2–3 nates; pedicels
nil; bractssmall, embracing the flowers; inflorescence in single umbel, bearing
flowers, sessile, white or reddish; fruit small, compressed, 8mm long, mericarps
longer than broad, curved, rounded at top, 7–9-ridged, secondary ridges
as prominent as the primary, reticulate between them; pericarp much thickened;
seed compressed laterally
Plant material used
aerial part or entire plant
Contains not less than 2% triterpene ester glycosides (asiaticoside and madecassoside).
Determination of asiaticoside and related triterpene ester glycosides by thin-layer
chromatography and spectroscopic analysis
Major chemical constituents
The major principles in Herba Centellae are the triterpenes asiatic acid and
madecassic acid, and their derived triterpene ester glycosides, asiaticoside
Dried drug for infusion; galenic preparations for oral administration. Powder
or extract (liquid or ointment) for topical application. Package in well-closed,
Uses supported by clinical data
Treatment of wounds, burns, and ulcerous skin ailments, and prevention of keloid
and hypertrophic scars. Extracts of the plant have been employed to treat second-
and third-degree burns. Extracts have been used topically to accelerate healing,
particularly in cases of chronic postsurgical and post-trauma wounds. Extracts
have been administered orally to treat stressinduced stomach and duodenal ulcers.
Uses described in pharmacopoeias and well
Herba Centellae is reported to be used in the treatment of leprous ulcers and
venous disorders Studies suggest that extracts of Centella asiatica cause regression
of inflammatory infiltration of the liver in cirrhosis patients. Further experimentation
is needed to confirm these findings.
Uses described in traditional medicine
Therapy of albinism, anaemia, asthma, bronchitis, cellulite, cholera, measles,
constipation, dermatitis, diarrhoea, dizziness, dysentery, dysmenorrhoea, dysuria,
epistaxis, epilepsy, haematemesis, haemorrhoids, hepatitis, hypertension, jaundice,
leukorrhoea, nephritis, nervous disorders, neuralgia, rheumatism, smallpox,
syphilis, toothache, urethritis, and varices; and as an antipyretic, analgesic,
anti-inflammatory, and “brain tonic” agent. Poultices have been
used to treat contusions, closed fractures, sprains, and furunculosis
Proven pharmacological activity
Antiulcer, Antileprosy, treatment of venous insufficiency
Allergy to plants of the Apiaceae family.
No information available.
Carcinogenesis, mutagenesis, impairment of fertility
Asiaticoside has been implicated as a possible skin carcinogen in rodents after
repeated topical application. Further experimentation is needed to substantiate
No information was available concerning drug interactions, drug and laboratory
test interactions, teratogenic or non-teratogenic effects on pregnancy, nursing
mothers, or paediatric use.
Allergic contact dermatitis has been associated with topical application of
C. asiatica. However, further testing revealed that these reactions may be due
to other ingredients in the preparations .
Oral dose: 0.33–0.68 g or by oral infusion of a similar amount three times