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Since May 10th 2008


Initial B


Brucea javanica
Buplureum falcatum


 

 

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Brucea javanica (L.) Merr. (Simaroubaceae)

Synonyms
Brucea amarissima Desv. ex Gomes, B. sumatrana Roxb., Gonus amarissimus Lour., Lussa amarissima O. Ktze

Local names
Biji makassar, bulah makassar, Java brucea, k’u-shen-tzu, kho sam, ko-sam, kusheng-tzu, nha dàm tùr, raat cha dat, raat dat, ratchadat, sàu dau rùng, xoan rùng, ya tan tzu, ya-dan-zi, yadãnzi

Description
A shrub or small tree, 1–3 m high; younger parts softly pubescent. Leaves compound-paripinnate; leaflets 5–11, oval-lanceolate, 5–10cm long by 2–4cm wide; apex acuminate, base broadly cuneate and often somewhat oblique; margin serrate; both surfaces densely pubescent, especially the underside. Flowers minute, purple, in numerous small cymes or clusters collected into axillary panicles. Sepals 4, connate at the base. Petals 4, villous, glandular at the tips. Male flowers, stamens 4, pistil reduced to a stigma; female flowers, stamens 4,much reduced. Ovary with 4 free carpels. Fruit and drupe ovoid, black when ripe. Seeds, compressed, rugose, blackish brown

Plant material used
dried ripe fruit or seed

Chemical assays
Contains bruceosides and related quassinoids. Quantitative content requirement to be established. Quantitative determination of quassinoid triterpenes by a high-performance liquid chromatographic method developed for the determination of bruceoside A

Major chemical constituents
Quassinoid triterpenes, including bruceantin, bruceantinol, bruceantinoside A, bruceins A–G and Q, brucein E 2-O-β-D-glucoside, bruceolide, bruceosides A–C, brusatol, dehydrobruceantinol, dehydrobruceins A and B, dehydrobrusatol, dihydrobrucein A, yadanzigan, yadanziolides A–D, and yadanziosides A–P predominate as the secondary metabolite constituents

Dosage forms
Seeds for decoction, or capsules. Store in airtight ontainer, protected from light and moisture

Medicinal uses
Uses supported by clinical data
None.

Uses described in pharmacopoeias and well established documents
Treatment of amoebic dysentery and malaria.

Uses described in traditional medicine
As a poultice on boils, to treat ringworm, whipworm, roundworm and tapeworm, scurf, centipede bites, haemorrhoids, and enlarged spleen. The seed and seed oil have been used in the treatment of warts and corns. Fructus Bruceae has been used in the treatment of trichomoniasis, corns and verrucae

Proven pharmacological activity
Animal studies
Amoebicidal and antibacterial, Antimalarial,

Human studies
Amoebicidal and antibacterial,

Contraindications
Fructus Bruceae should not be administered to children or pregnant women (6).

Warnings
No information available.

Precautions
Pregnancy: teratogenic and non-teratogenic effects
No data available. Preparations containing Fructus Bruceae must not be administered to pregnant women.

Nursing mothers
Excretion of Fructus Bruceae into breast milk and its effects on infants have not been established; therefore this drug should not be administered to nursing women.

Paediatric use
Fructus Bruceae should not be administered to young children.

Other precautions
No information available about general precautions or precautions concerning carcinogenesis, mutagenesis, or impairment of fertility; drug interactions; or drug and laboratory test interactions.

Adverse reactions
Some cases of anaphylaxis have been reported after external applications of the fruits of B. javanica.

Posology
Daily dose to treat amoebiasis, 4–16g as a decoction or powder in three divided doses for 3–7 days; to treat malaria, 3–6g in three divided doses after meals for 4 or 5 days

 

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